Missed connections: As people age, memory-related brain activity loses cohesion
Published on 26-11-2016 - at 02:02' by Science Daily

Groups of brain regions that synchronize their activity during memory tasks become smaller and more numerous as people age, according to a study published in PLOS Computational Biology.

Typically, research on brain activity relies on average brain measurements across entire groups of people. In a new study, Elizabeth Davison of Princeton University, New Jersey, and colleagues describe a novel method to characterize and compare the brain dynamics of individual people.

The researchers used functional magnetic resonance imaging (fMRI) to record healthy people’s brain activity during memory tasks, attention tasks, and at rest. For each person, fMRI data was recast as a network composed of brain regions and the connections between them. The scientists then use this network to measure how closely different groups of connections changed together over time.

They found that, regardless of whether a person is using memory, directing attention, or resting, the number of synchronous groups of connections within one brain is consistent for that person. However, between people, these numbers vary dramatically.

During memory specifically, variations between people are closely linked to age. Younger participants have only a few large synchronous groups that link nearly the entire brain in coordinated activity, while older participants show progressively more and smaller groups of connections, indicating loss of cohesive brain activity — even in the absence of memory impairment.

"This method elegantly captures important differences between individual brains, which are often complex and difficult to describe," Davison says. "The resulting tools show promise for understanding how different brain characteristics are related to behavior, health, and disease."

Future work will investigate how to use individual brain signatures to differentiate between healthily aging brains and brains with age-related impairments.

JPEG - 26.1 kb
The older age group experiences a dramatic increase in the number of groups of closely related activity that each brain region belongs to. This is reflective of the overall increase in the number of these groups with age.

Kwamamaza
Comments

YOUR OPINION ABOUT THIS ARTICLE

RULES AND REGULATIONS:
Do not post comments that are defamatory, divisive and blasphemous.
If you wish to receive a quick response to your opinion/comments, please provide your email address in the space provided.
Your comments will appear after moderation from IGIHE.com.
In case the above regulations are not observed, your comments might not appear or will be deleted. Thank you!